Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis

Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis

Abstract Background Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS). However, platycodon D (PLD) has emerged as a key anti-inflammatory mediator in the inflammatory progression of various respiratory diseases. This study aim...

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Bibliographic Details
Main Authors: Ruizhi Wang, Yongchun Wang, He Liu, Jinxiang Zhu, Caishan Fang, Weizhen Xu, Zesheng Lu, Yajie Yan, Weiping He, Yan Ruan, Min Zhou
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Chinese Medicine
Subjects:
Pyroptosis
Chronic rhinosinusitis
Platycodon D
NLRP3 inflammasome
Nrf2/HO-1 antioxidant signaling pathway
Online Access:https://doi.org/10.1186/s13020-024-00897-y

Internet

https://doi.org/10.1186/s13020-024-00897-y

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