A single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate

A single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate

Abstract Background A broad range of aromatic compounds can be degraded by enteric bacteria, and hydroxyphenylacetic acid (HPA) degrading bacteria are the most widespread. Majority of Escherichia coli strains can use both the structural isomers of HPA, 3HPA and 4HPA, as the sole carbon source, which...

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Bibliographic Details
Main Authors: Hanseol Kim, Sinyeon Kim, Dohyeon Kim, Sung Ho Yoon
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Microbiology
Subjects:
Hydroxyphenylacetic acid
4-hydroxyphenylacetate 3-hydroxylase
Structural isomer
Substrate specificity
Online Access:http://link.springer.com/article/10.1186/s12866-020-01798-4

Internet

http://link.springer.com/article/10.1186/s12866-020-01798-4

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