Case report: B7-H3 CAR-T therapy partially controls tumor growth in a basal cell carcinoma patient

Case report: B7-H3 CAR-T therapy partially controls tumor growth in a basal cell carcinoma patient

B7-H3 is over-expressed in multiple types of solid tumors, making it an ideal target for chimeric antigen receptor (CAR)-T therapy. Here, we first report a case of multiple basal cell carcinoma (BCC) patient treated with humanized monoclonal anti-B7-H3 CAR-T cells through direct intratumoral injecti...

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Bibliographic Details
Main Authors: Gang Hu, Guangchao Li, Wei Wen, Wen Ding, Zhao Zhou, Yongwei Zheng, Taoyuan Huang, Junnan Ren, Rongyi Chen, Dingheng Zhu, Renliang He, Yunsheng Liang, Min Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
basal cell carcinomas
skin cancers
CAR-T cell therapy
B7-H3
CD276
intratumoral injection
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.956593/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.956593/full

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