Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells

Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells

Clostridioides difficile is the major cause of antibiotic-associated colitis (CDAC) with increasing prevalence in morbidity and mortality. Severity of CDAC has been attributed to hypervirulent C. difficile strains, which in addition to toxin A and B (TcdA, TcdB) produce the binary toxin C. difficile...

Full description

Bibliographic Details
Main Authors: Isabel Marquardt, Josefine Jakob, Jessica Scheibel, Julia Danielle Hofmann, Frank Klawonn, Meina Neumann-Schaal, Ralf Gerhard, Dunja Bruder, Lothar Jänsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Microbiology
Subjects:
MAIT cells
C. difficile
TcdA
TcdB
CDT
CDAC
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.752549/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.752549/full

Similar Items