Marine Natural Products Acting on the Acetylcholine-Binding Protein and Nicotinic Receptors: From Computer Modeling to Binding Studies and Electrophysiology

Marine Natural Products Acting on the Acetylcholine-Binding Protein and Nicotinic Receptors: From Computer Modeling to Binding Studies and Electrophysiology

For a small library of natural products from marine sponges and ascidians, in silico docking to the Lymnaea stagnalis acetylcholine-binding protein (AChBP), a model for the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), was carried out and the possibility of complex formation...

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Bibliographic Details
Main Authors: Denis Kudryavtsev, Tatyana Makarieva, Natalia Utkina, Elena Santalova, Elena Kryukova, Christoph Methfessel, Victor Tsetlin, Valentin Stonik, Igor Kasheverov
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Marine Drugs
Subjects:
marine natural compounds
acetylcholine-binding protein
nicotinic acetylcholine receptors
computer modeling
radioligand assay
electrophysiology
Online Access:http://www.mdpi.com/1660-3397/12/4/1859

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http://www.mdpi.com/1660-3397/12/4/1859

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