Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

Immune checkpoint blockade (ICB) therapy targeting PD-L1 via monoclonal antibody (mAb) has shown extensive clinical benefits in the diverse types of advanced malignancies. However, most patients are completely refractory to ICB therapy owing to the PD-L1 recycling mechanism. Herein, we propose photo...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Youngjoo Lee, Sukyung Song, Suah Yang, Jinseong Kim, Yujeong Moon, Nayeon Shim, Hong Yeol Yoon, Sehoon Kim, Man Kyu Shim, Kwangmeyung Kim
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Elsevier 2024-03-01
Sraith:Acta Pharmaceutica Sinica B
Ábhair:
Cancer immunotherapy
Immune checkpoint blockade
PEGylated liposome
Crosslinked lipid nanoparticles
Anti-PD-L1 peptide
Tumor-targeting
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S221138352300360X

Ar líne

http://www.sciencedirect.com/science/article/pii/S221138352300360X

Míreanna comhchosúla