Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

Immune checkpoint blockade (ICB) therapy targeting PD-L1 via monoclonal antibody (mAb) has shown extensive clinical benefits in the diverse types of advanced malignancies. However, most patients are completely refractory to ICB therapy owing to the PD-L1 recycling mechanism. Herein, we propose photo...

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Bibliografische gegevens
Hoofdauteurs: Youngjoo Lee, Sukyung Song, Suah Yang, Jinseong Kim, Yujeong Moon, Nayeon Shim, Hong Yeol Yoon, Sehoon Kim, Man Kyu Shim, Kwangmeyung Kim
Formaat: Artikel
Taal:English
Gepubliceerd in: Elsevier 2024-03-01
Reeks:Acta Pharmaceutica Sinica B
Onderwerpen:
Cancer immunotherapy
Immune checkpoint blockade
PEGylated liposome
Crosslinked lipid nanoparticles
Anti-PD-L1 peptide
Tumor-targeting
Online toegang:http://www.sciencedirect.com/science/article/pii/S221138352300360X

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http://www.sciencedirect.com/science/article/pii/S221138352300360X

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