In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole cross-linked with Hydroxamic acid by certain linkers

In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole cross-linked with Hydroxamic acid by certain linkers

New hybrid molecules of Benzothiazole cross-linked with hydroxamic acid through an amino acid or aminoalkanoic acid are suggested. All the synthesized hybrid molecules (2A-E) were subjected to molecular docking to evaluate their binding affinities with histone deacetylase enzyme (HDAC8, PDB ID: 1T6...

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Bibliographic Details
Main Authors: yazen alqaysi, Shakir M. Alwan, Ashour H. Dawood
Format: Article
Language:English
Published: College of Pharmacy / Mustansiriyah University 2024-01-01
Series:Al-Mustansiriyah Journal of Pharmaceutical Sciences
Subjects:
Benzothiazole
Amino acids
Molecular hybridization
Vorinostat
HDACs inhibitors
Online Access:https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1006

Internet

https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1006

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