Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies <i>TOP2A</i> as a Therapeutic Target for Rectal Cancer

Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies <i>TOP2A</i> as a Therapeutic Target for Rectal Cancer

Rectal cancer is a common disease with high mortality rates and limited therapeutic options. Here we combined the gene expression signatures of rectal cancer patients with the reverse drug-induced gene-expression profiles to identify drug repositioning candidates for cancer therapy. Among the predic...

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Bibliographic Details
Main Authors: Robson Francisco Carvalho, Luisa Matos do Canto, Sarah Santiloni Cury, Torben Frøstrup Hansen, Lars Henrik Jensen, Silvia Regina Rogatto
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
rectal cancer
drug repositioning
reverse expression of signature genes
gene expression features
drug reversal potency scoring
Online Access:https://www.mdpi.com/2072-6694/13/21/5492

Internet

https://www.mdpi.com/2072-6694/13/21/5492

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