Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects

Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects

Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas disease. As recent studies have de-monstrated cardiotoxic effects of Nfx, we attempted to determine whether Bz behaves similarly. Bz reached the heart tissue of male rats after intragastric administration. No cytosolic Bz nitrored...

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Bibliographic Details
Main Authors: María Montalto de Mecca, Laura C Bartel, Carmen Rodríguez de Castro, José A Castro
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2008-09-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Chagas disease
benznidazole
nifurtimox
nitroreduction
cardiopathy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000600007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000600007

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