Identification of colorectal cancer patients with tumors carrying the <it>TP53 </it>mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy

Identification of colorectal cancer patients with tumors carrying the <it>TP53 </it>mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy

<p>Abstract</p> <p>Background</p> <p>Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients, biomarkers to predict those who may benefit from the therapy have not been ide...

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Main Authors: Tsuchiya Eiju, Sakuma Yuji, Matsukuma Shoichi, Yoshihara Mitsuyo, Sekiyama Akiko, Sekiguchi Hironobu, Shiozawa Manabu, Tsuchida Kazuhito, Sugano Nobuhiro, Suda Tetsuji, Godai Ten-i, Kameda Yoichi, Akaike Makoto, Miyagi Yohei
Format: Article
Language:English
Published: BMC 2009-12-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/9/420

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http://www.biomedcentral.com/1471-2407/9/420

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