Construction of an immunotoxin via site-specific conjugation of anti-Her2 IgG and engineered Pseudomonas exotoxin A

Construction of an immunotoxin via site-specific conjugation of anti-Her2 IgG and engineered Pseudomonas exotoxin A

Abstract Background Immunotoxins consisting of a toxin from bacteria or plants and a targeting module have been developed as potent anti-cancer therapeutics. The majority of them, especially those in preclinical or clinical testing stages, are fusion proteins of a toxin and antibody fragment. Immuno...

Full description

Bibliographic Details
Main Authors: Byeong Sung Lee, Yumi Lee, Jisoo Park, Bo Seok Jeong, Migyeong Jo, Sang Taek Jung, Tae Hyeon Yoo
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Biological Engineering
Subjects:
Immunotoxin
Site-specific conjugation
Immunoglobulin G
Unnatural amino acid
Pseudomonas Exotoxin A
Online Access:http://link.springer.com/article/10.1186/s13036-019-0188-x

Internet

http://link.springer.com/article/10.1186/s13036-019-0188-x

Similar Items