Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8+ T Cell Activation and Expansion by Promoting T Cell–APC Interactions In Vivo

Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8+ T Cell Activation and Expansion by Promoting T Cell–APC Interactions In Vivo

Naïve T cell activation in secondary lymphoid organs such as lymph nodes (LNs) occurs upon recognition of cognate antigen presented by antigen presenting cells (APCs). T cell activation requires cytoskeleton rearrangement and sustained interactions with APCs. Enabled/vasodilator-stimulated phosphopr...

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Bibliographic Details
Main Authors: Monique M. Waldman, Jeremy T. Rahkola, Ashton L. Sigler, Jeffrey W. Chung, Benjamin A. S. Willett, Ross M. Kedl, Rachel S. Friedman, Jordan Jacobelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
T cell
cytoskeleton
VASP
T cell activation
T cell motility
two-photon microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.856977/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.856977/full

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