Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues.

Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues.

Recent advances in human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues provide a unique opportunity for cardiotoxic assessment of pharmaceutical and environmental compounds. Here, we developed a series of automated data processing algorithms to assess changes in action potential...

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Bibliographic Details
Main Authors: Arvin H Soepriatna, Allison Navarrete-Welton, Tae Yun Kim, Mark C Daley, Peter Bronk, Celinda M Kofron, Ulrike Mende, Kareen L K Coulombe, Bum-Rak Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0280406

Internet

https://doi.org/10.1371/journal.pone.0280406

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