3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

FGF signaling plays an essential role in lung development, homeostasis, and regeneration. We employed mouse 3D cell culture models and imaging to study ex vivo the role of FGF ligands and the interplay of FGF signaling with epithelial growth factor (EGF) and WNT signaling pathways in lung epithelial...

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Bibliographic Details
Main Authors: Anas Rabata, Radek Fedr, Karel Soucek, Ales Hampl, Zuzana Koledova
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
3D cell culture
epithelial cell
FGF signaling
lung
morphogenesis
organoid
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00574/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00574/full

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