Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network

Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network

Here, the authors studied how cerebellar stimulation alleviates levodopa-induced dyskinesia (LID). They demonstrated that Purkinje cell opto-stimulation is sufficient to prevent LID development and can normalize brain activity in a wide motor network in mice.

Bibliographic Details
Main Authors: Bérénice Coutant, Jimena Laura Frontera, Elodie Perrin, Adèle Combes, Thibault Tarpin, Fabien Menardy, Caroline Mailhes-Hamon, Sylvie Perez, Bertrand Degos, Laurent Venance, Clément Léna, Daniela Popa
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30844-0

Internet

https://doi.org/10.1038/s41467-022-30844-0

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