The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma

The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma

Multiple myeloma is a malignancy of terminally differentiated plasma cells, characterized by an extreme genetic heterogeneity that poses great challenges for its successful treatment. Due to antibody overproduction, MM cells depend on the precise regulation of the protein degradation systems. Despit...

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Bibliographic Details
Main Authors: Tina Paradzik, Cecilia Bandini, Elisabetta Mereu, Maria Labrador, Elisa Taiana, Nicola Amodio, Antonino Neri, Roberto Piva
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
multiple myeloma
proteasome inhibitors
drug resistance
combinatorial treatment
synthetic lethality
Online Access:https://www.mdpi.com/2072-6694/13/6/1235

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https://www.mdpi.com/2072-6694/13/6/1235

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