Destin2: Integrative and cross-modality analysis of single-cell chromatin accessibility data

Destin2: Integrative and cross-modality analysis of single-cell chromatin accessibility data

We propose Destin2, a novel statistical and computational method for cross-modality dimension reduction, clustering, and trajectory reconstruction for single-cell ATAC-seq data. The framework integrates cellular-level epigenomic profiles from peak accessibility, motif deviation score, and pseudo-gen...

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Bibliographic Details
Main Authors: Peter Y. Guan, Jin Seok Lee, Lihao Wang, Kevin Z. Lin, Wenwen Mei, Li Chen, Yuchao Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Genetics
Subjects:
single-cell epigenomics
single-cell ATAC-seq
chromatin accessibility
single-cell multiome
cross-modality integration
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1089936/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1089936/full

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