Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress

Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress

Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...

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Bibliographic Details
Main Authors: Chandramohan Chitraju, Martin Trötzmüller, Jürgen Hartler, Heimo Wolinski, Gerhard G. Thallinger, Achim Lass, Rudolf Zechner, Robert Zimmermann, Harald C. Köfeler, Friedrich Spener
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Journal of Lipid Research
Subjects:
lipidomics
mass spectrometry
high-fat diet
fasting
steatosis
principal component analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520431918

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http://www.sciencedirect.com/science/article/pii/S0022227520431918

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