Interruption of post-Golgi STING trafficking activates tonic interferon signaling

Interruption of post-Golgi STING trafficking activates tonic interferon signaling

Microbial DNA is recognized by the cGAS-STING pathway, which leads to a type I interferon response. Here authors show that a basal flux of interferon activation could also be triggered by interference with STING trafficking from the Golgi apparatus to the lysosomes.

Bibliographic Details
Main Authors: Xintao Tu, Ting-Ting Chu, Devon Jeltema, Kennady Abbott, Kun Yang, Cong Xing, Jie Han, Nicole Dobbs, Nan Yan
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33765-0

Internet

https://doi.org/10.1038/s41467-022-33765-0

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