Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease

Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease

We have compared the efficacy of two Leishmania (Leishmania) major vaccines, one genetically attenuated (DHFR-TS deficient organisms), the other inactivated [autoclaved promastigotes (ALM) with bacillus Calmete-Guérin (BCG)], in protecting rhesus macaques (Macaca mulatta) against infection with viru...

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Bibliographic Details
Main Authors: VF Amaral, A Teva, MP Oliveira-Neto, AJ Silva, MS Pereira, E Cupolillo, R Porrozzi, SG Coutinho, C Pirmez, SM Beverley, G Grimaldi Jr
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2002-10-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Leishmania (L.) major
rhesus macaques (Macaca mulatta)
vaccination
attenuated and killed promastigotes
bacillus Calmete-Guerin (BCG)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000700019

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000700019

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