NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

Abstract Background The NSD2 p.E1099K (EK) mutation is shown to be enriched in patients with relapsed acute lymphoblastic leukemia (ALL), indicating a role in clonal evolution and drug resistance. Results To uncover 3D chromatin architecture-related mechanisms underlying drug resistance, we perform...

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Bibliographic Details
Main Authors: Sonali Narang, Nikki A. Evensen, Jason Saliba, Joanna Pierro, Mignon L. Loh, Patrick A. Brown, Pandurang Kolekar, Heather Mulder, Ying Shao, John Easton, Xiaotu Ma, Aristotelis Tsirigos, William L. Carroll
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Genome Biology
Subjects:
Relapsed acute lymphoblastic leukemia
NSD2
Clonal evolution
Chromatin architecture
Online Access:https://doi.org/10.1186/s13059-023-02905-0

Internet

https://doi.org/10.1186/s13059-023-02905-0

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