TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy

Abstract Background Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in TLE is well known in animal models as well as in patients; however, the...

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Bibliographic Details
Main Authors: Laura Mundrucz, Angéla Kecskés, Nóra Henn-Mike, Péter Kóbor, Péter Buzás, Rudi Vennekens, Miklós Kecskés
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-023-01604-3