Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors

Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors

Cyclin-dependent kinase 5 (Cdk5) is an atypical proline-directed serine/threonine protein kinase well-characterized for its role in the central nervous system rather than in the cell cycle. Indeed, its dysregulation has been strongly implicated in the progression of synaptic dysfunction and neurodeg...

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Bibliographic Details
Main Authors: Miriana Di Stefano, Salvatore Galati, Gabriella Ortore, Isabella Caligiuri, Flavio Rizzolio, Costanza Ceni, Simone Bertini, Giulia Bononi, Carlotta Granchi, Marco Macchia, Giulio Poli, Tiziano Tuccinardi
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
virtual screening
machine learning
kinase
CDK5
Online Access:https://www.mdpi.com/1422-0067/23/18/10653

Internet

https://www.mdpi.com/1422-0067/23/18/10653

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