Divergent Metabolic Effects of Metformin Merge to Enhance Eicosapentaenoic Acid Metabolism and Inhibit Ovarian Cancer In Vivo

Divergent Metabolic Effects of Metformin Merge to Enhance Eicosapentaenoic Acid Metabolism and Inhibit Ovarian Cancer In Vivo

Metformin is being actively repurposed for the treatment of gynecologic malignancies including ovarian cancer. We investigated if metformin induces analogous metabolic changes across ovarian cancer cells. Functional metabolic analysis showed metformin caused an immediate and sustained decrease in ox...

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Bibliographic Details
Main Authors: Mary P. Udumula, Laila M. Poisson, Indrani Dutta, Nivedita Tiwari, Seongho Kim, Jasdeep Chinna-Shankar, Ghassan Allo, Sharif Sakr, Miriana Hijaz, Adnan R. Munkarah, Shailendra Giri, Ramandeep Rattan
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
ovarian cancer
metabolomics
metformin
omega-3 fatty acids
DHA
EPA
Online Access:https://www.mdpi.com/2072-6694/14/6/1504

Internet

https://www.mdpi.com/2072-6694/14/6/1504

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