Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation

Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation

Abstract Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. However, tumors are comprised of a heterogeneous collection of c...

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Bibliographic Details
Main Authors: Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Cancer
Subjects:
Clonal heterogeneity
Dasatinib
EMT
HNSCC
Invasion
ITH
Online Access:https://doi.org/10.1186/s12943-021-01384-w

Internet

https://doi.org/10.1186/s12943-021-01384-w

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