Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or 1,2,3-triazole C-5-aryl bonds were investigated by physical and computational techniques. The barrier t...

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Bibliographic Details
Main Authors: Fernanda Meloni, William D.G. Brittain, Louise Male, Cécile S. Le Duff, Benjamin R. Buckley, Andrew G. Leach, John S. Fossey
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Tetrahedron Chem
Subjects:
Chirality
Atropisomer
Axial chirality
Triazole
Click chemistry
Crystal Structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2666951X21000048

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http://www.sciencedirect.com/science/article/pii/S2666951X21000048

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