Tools and tactics to define specificity of metabolic chemical reporters

Tools and tactics to define specificity of metabolic chemical reporters

Metabolic chemical reporters (MCRs) provide easily accessible means to study glycans in their native environments. However, because monosaccharide precursors are shared by many glycosylation pathways, selective incorporation has been difficult to attain. Here, a strategy for defining the selectivity...

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Bibliographic Details
Main Authors: Mana Mohan Mukherjee, Michelle R. Bond, Lara K. Abramowitz, Devin Biesbrock, Carolyn C. Woodroofe, Eun Ju Kim, Rolf E. Swenson, John A. Hanover
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
bioorthogonal chemistry
metabolic chemical reporters
O- and N-glycans
hexosamine biosynthetic pathway
tools and tactics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1286690/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1286690/full

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