Structural Insights into the Azole Resistance of the <i>Candida albicans</i> Darlington Strain Using <i>Saccharomyces cerevisiae</i> Lanosterol 14α-Demethylase as a Surrogate

Structural Insights into the Azole Resistance of the <i>Candida albicans</i> Darlington Strain Using <i>Saccharomyces cerevisiae</i> Lanosterol 14α-Demethylase as a Surrogate

Target-based azole resistance in <i>Candida albicans</i> involves overexpression of the <i>ERG11</i> gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of <i>Candida albicans</i> LDM (...

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Bibliographic Details
Main Authors: Danyon O. Graham, Rajni K. Wilson, Yasmeen N. Ruma, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Journal of Fungi
Subjects:
azole resistance
<i>Candida albicans</i>
Darlington strain
<i>Saccharomyces cerevisiae</i>
CYP51
lanosterol 14α-methylase
Online Access:https://www.mdpi.com/2309-608X/7/11/897

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https://www.mdpi.com/2309-608X/7/11/897

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