PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

Abstract TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune responses. While the oligomerization of TBK1 is critical for its full activation, the molecular mechanism of how TBK1 forms oligomers remains unclear. Here, we show that protein tyrosine kinase 2 beta (PTK2B)...

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Bibliographic Details
Main Authors: Yongfang Lin, Jing Yang, Qili Yang, Sha Zeng, Jiayu Zhang, Yuanxiang Zhu, Yuxin Tong, Lin Li, Weiqi Tan, Dahua Chen, Qinmiao Sun
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43419-4

Internet

https://doi.org/10.1038/s41467-023-43419-4

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