Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

The zinc finger CCCTC-binding protein (CTCF) carries out many functions in the cell. Although previous studies sought to explain CTCF multivalency based on sequence composition of binding sites, few examined how CTCF post-translational modification (PTM) could contribute to function. Here, we perfor...

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Bibliographic Details
Main Authors: Brian C Del Rosario, Andrea J Kriz, Amanda M Del Rosario, Anthony Anselmo, Christopher J Fry, Forest M White, Ruslan I Sadreyev, Jeannie T Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
CTCF
post-translational modification
cell cycle
chromosome architecture
PLK1
Online Access:https://elifesciences.org/articles/42341

Internet

https://elifesciences.org/articles/42341

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