Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice

Objective: Osteoarthritis (OA), widely seen in the elderly, is featured by cartilage degradation, subchondral bone remolding, and synovium inflammation. Currently, there is no cure for OA development. Phillygenin (PHI), an active ingredient from the Forsythiae Fructus, possesses many biological prop...

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Bibliographic Details
Main Authors: Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Osteoarthritis
Inflammation
Oxidative stress
Phillygenin
Nrf2/NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000177

Internet

http://www.sciencedirect.com/science/article/pii/S2214031X23000177

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