A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis.

A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis.

Microbial dysbiosis commonly occurs in patients with inflammatory bowel diseases (IBD). Exogenous causes of dysbiosis such as antibiotics and diet are well described, but host derived causes are understudied. A20 is a potent regulator of signals triggered by microbial pattern molecules, and A20 regu...

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Bibliographic Details
Main Authors: Alice Talpin, Michael G Kattah, Rommel Advincula, Douglas Fadrosh, Kole Lynch, Brandon LaMere, Kei E Fujimura, Nabeetha A Nagalingam, Barbara A Malynn, Susan V Lynch, Averil Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218999

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https://doi.org/10.1371/journal.pone.0218999

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