Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D<sub>3</sub> Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Two 24-fluoro-25-hydroxyvitamin D<sub>3</sub> analogues (<b>3</b>,<b>4</b>) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D<sub>3</sub> side-chain C24 position was achieved via Sharpless dihydroxylation, and...

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Bibliographic Details
Main Authors: Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
human CYP24A1
synthesis
vitamin D<sub>3</sub> metabolite
24-fluoro-25-hydroxyvitamin D<sub>3</sub> analogues
Sharpless dihydroxylation
Online Access:https://www.mdpi.com/1422-0067/22/21/11863

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https://www.mdpi.com/1422-0067/22/21/11863

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