Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

Abstract The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To exam...

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Bibliographic Details
Main Authors: Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Format: Article
Language:English
Published: Nature Portfolio 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19227-5

Internet

https://doi.org/10.1038/s41467-020-19227-5

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