Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson's disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD genes in PD...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-05-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1010760 |