Epigenomic profiling of isolated blood cell types reveals highly specific B cell smoking signatures and links to disease risk

Epigenomic profiling of isolated blood cell types reveals highly specific B cell smoking signatures and links to disease risk

Abstract Background Tobacco smoking alters the DNA methylation profiles of immune cells which may underpin some of the pathogenesis of smoking-associated diseases. To link smoking-driven epigenetic effects in specific immune cell types with disease risk, we isolated six leukocyte subtypes, CD14+ mon...

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Bibliographic Details
Main Authors: Xuting Wang, Michelle R. Campbell, Hye-Youn Cho, Gary S. Pittman, Suzanne N. Martos, Douglas A. Bell
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Tobacco smoking
Blood cell types
Epigenome-wide association study
Genetic variation
Memory B cell
Online Access:https://doi.org/10.1186/s13148-023-01507-8

Internet

https://doi.org/10.1186/s13148-023-01507-8

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