A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

Abstract Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection when compared to vaccination with replication-deficient, radiation-attenuated PfSPZ. However, the requirement...

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Bibliographic Details
Main Authors: Debashree Goswami, Hardik Patel, William Betz, Janna Armstrong, Nelly Camargo, Asha Patil, Sumana Chakravarty, Sean C Murphy, B Kim Lee Sim, Ashley M Vaughan, Stephen L Hoffman, Stefan HI Kappe
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:EMBO Molecular Medicine
Subjects:
Malaria
Pre-erythrocytic
Genetically Attenuated Parasite Vaccine
Sporozoite
Liver Stage
Online Access:https://doi.org/10.1038/s44321-024-00057-7

Internet

https://doi.org/10.1038/s44321-024-00057-7

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