An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice

An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice

Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of Venezuelan equine encephalitis virus (VEEV). Selected...

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Bibliographic Details
Main Authors: Callie E. Bounds, Frances E. Terry, Leonard Moise, Drew Hannaman, William D. Martin, Anne S. De Groot, John J. Suschak, Lesley C. Dupuy, Connie S. Schmaljohn
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
dna vaccine
epitope-based vaccine
ebola virus
ebov
genome-derived vaccine
mice
peptide vaccine
sudan virus
sudv
t cell epitope
venezuelan equine encephalitis virus
veev
Online Access:http://dx.doi.org/10.1080/21645515.2017.1329788

Internet

http://dx.doi.org/10.1080/21645515.2017.1329788

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