R-spondin3 is a myokine that differentiates myoblasts to type I fibres

Abstract Muscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the contractile and metabolic properties of skeletal muscle tissue. The maintenance of type I fibres is essential for the prevention of obesity and the treatment of muscle atrophy caused by type 2 dia...

Full description

Bibliographic Details
Main Authors: Yoshitaka Mita, Haonan Zhu, Yasuro Furuichi, Hiroki Hamaguchi, Yasuko Manabe, Nobuharu L. Fujii
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16640-2