Mutated IL-32θ (A94V) inhibits COX2, GM-CSF and CYP1A1 through AhR/ARNT and MAPKs/NF-κB/AP-1 in keratinocytes exposed to PM10

Mutated IL-32θ (A94V) inhibits COX2, GM-CSF and CYP1A1 through AhR/ARNT and MAPKs/NF-κB/AP-1 in keratinocytes exposed to PM10

Abstract Exposure to particulate matter (PM) in the air harms human health. Most studies on particulate matter’s (PM) effects have primarily focused on respiratory and cardiovascular diseases. Recently, IL-32θ, one of the IL-32 isoforms, has been demonstrated to modulate cancer development and infla...

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Bibliographic Details
Main Authors: Jinju Kim, Chae-Min Lim, Nahyun Kim, Hong-Gyum Kim, Jin-Tae Hong, Young Yang, Do-Young Yoon
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
HaCaT
Fine dust
PM10
PAH
MAPK
Skin inflammation
Online Access:https://doi.org/10.1038/s41598-024-83159-z

Internet

https://doi.org/10.1038/s41598-024-83159-z

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