Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

Background: Glucocorticoids are among the most commonly prescribed drugs, but there is no biomarker that can quantify their action. The aim of the study was to identify and validate circulating biomarkers of glucocorticoid action. Methods: In a randomized, crossover, single-blind, discovery study, 1...

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Bibliographic Details
Main Authors: Dimitrios Chantzichristos, Per-Arne Svensson, Terence Garner, Camilla AM Glad, Brian R Walker, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Penelope Trimpou, Roland H Stimson, Stina W Borresen, Ulla Feldt-Rasmussen, Per-Anders Jansson, Stanko Skrtic, Adam Stevens, Gudmundur Johannsson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
glucocorticoids
biomarkers
multi-omics
microRNA
gene expression
metabolites
Online Access:https://elifesciences.org/articles/62236

Internet

https://elifesciences.org/articles/62236

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