Hyperalgesic effect of subarachnoid administration of phentolamine in mice

Background and objectives: Painful phenomenon is one of the most important and complex experiences. Phentolamine is a non-selective alpha-adrenergic antagonist. The objective of this study was to compare the effect of increasing doses of phentolamine into subarachnoid space in rats in the modulation...

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Bibliographic Details
Main Authors: Desiré Carlos Callegari, João Antônio Correa, Oscar César Pires, Renan Batista Corrêa Braga, Ana Flávia Marques Gimbo, Adriana Aparecida de Souza, Marta Helena Rovani Pires, Elton Constantino, Irimar de Paula Posso
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Brazilian Journal of Anesthesiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0104001414001304