Deletion of Vhl in Dmp1-Expressing Cells Causes Microenvironmental Impairment of B Cell Lymphopoiesis

Deletion of Vhl in Dmp1-Expressing Cells Causes Microenvironmental Impairment of B Cell Lymphopoiesis

The contributions of skeletal cells to the processes of B cell development in the bone marrow (BM) have not been completely described. The von-Hippel Lindau protein (VHL) plays a key role in cellular responses to hypoxia. Previous work showed that Dmp1-Cre;Vhl conditional knockout mice (VhlcKO), whi...

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Bibliographic Details
Main Authors: Betsabel Chicana, Nastaran Abbasizadeh, Christian Burns, Hanna Taglinao, Joel A. Spencer, Jennifer O. Manilay
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
B lymphocytes
osteoimmunology
hypoxia
microenvironment
bone marrow niches
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.780945/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.780945/full

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