Perilipin 5 deletion protects against nonalcoholic fatty liver disease and hepatocellular carcinoma by modulating lipid metabolism and inflammatory responses

Perilipin 5 deletion protects against nonalcoholic fatty liver disease and hepatocellular carcinoma by modulating lipid metabolism and inflammatory responses

Abstract The molecular mechanisms underlying the transition from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) are incompletely understood. During the development of NAFLD, Perilipin 5 (PLIN5) can regulate lipid metabolism by suppressing lipolysis and preventing lipotoxi...

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Main Authors: Paola Berenice Mass-Sanchez, Marinela Krizanac, Paula Štancl, Marvin Leopold, Kathrin M. Engel, Eva Miriam Buhl, Josef van Helden, Nikolaus Gassler, Jürgen Schiller, Rosa Karlić, Diana Möckel, Twan Lammers, Steffen K. Meurer, Ralf Weiskirchen, Anastasia Asimakopoulos
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01860-4

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https://doi.org/10.1038/s41420-024-01860-4

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