Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke

Abstract Background Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymo...

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Main Authors: Yuan Wu, Junjie Zhao, Yonglin Zhao, Tingqin Huang, Xudong Ma, Honggang Pang, Ming Zhang
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Medical Genetics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12881-019-0888-6
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author Yuan Wu
Junjie Zhao
Yonglin Zhao
Tingqin Huang
Xudong Ma
Honggang Pang
Ming Zhang
author_facet Yuan Wu
Junjie Zhao
Yonglin Zhao
Tingqin Huang
Xudong Ma
Honggang Pang
Ming Zhang
author_sort Yuan Wu
collection DOAJ
description Abstract Background Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymorphisms influenced IS risk in the Han Chinese population. Methods We selected 477 patients and 495 controls to do a case-control study, and five SNPs in CYP4F2 gene were successfully genotyped. And we evaluated the associations using the Chi-squared test, independent sample t test, and genetic models analyses. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results In this study, rs12459936 and rs3093144 were associated with IS risk in the overall. After stratified analysis by age (> 61 years), rs3093193 and rs3093144 were related to an increased risk of IS, whereas rs12459936 was related to a decreased risk of IS. In addition, we found that three SNPs (rs3093193, rs3093144 and rs12459936) were associated with the susceptibility to IS in males. We also found five SNPs in the CYP4F2 gene had strong linkage. Conclusions Three SNPs (rs3093193, rs3093144 and rs12459936) in the CYP4F2 were associated with IS risk in a Chinese Han population. And, CYP4F2 gene may be involved in the development of IS.
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spelling doaj.art-2feaa82e1840494e94ee66dbfb8498122022-12-21T22:10:06ZengBMCBMC Medical Genetics1471-23502019-09-012011910.1186/s12881-019-0888-6Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic strokeYuan Wu0Junjie Zhao1Yonglin Zhao2Tingqin Huang3Xudong Ma4Honggang Pang5Ming Zhang6Department of Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Oncology Hospital, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Surrounding Vascular, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Background Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymorphisms influenced IS risk in the Han Chinese population. Methods We selected 477 patients and 495 controls to do a case-control study, and five SNPs in CYP4F2 gene were successfully genotyped. And we evaluated the associations using the Chi-squared test, independent sample t test, and genetic models analyses. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results In this study, rs12459936 and rs3093144 were associated with IS risk in the overall. After stratified analysis by age (> 61 years), rs3093193 and rs3093144 were related to an increased risk of IS, whereas rs12459936 was related to a decreased risk of IS. In addition, we found that three SNPs (rs3093193, rs3093144 and rs12459936) were associated with the susceptibility to IS in males. We also found five SNPs in the CYP4F2 gene had strong linkage. Conclusions Three SNPs (rs3093193, rs3093144 and rs12459936) in the CYP4F2 were associated with IS risk in a Chinese Han population. And, CYP4F2 gene may be involved in the development of IS.http://link.springer.com/article/10.1186/s12881-019-0888-6Ischemic stroke (IS)Cytochrome P450 family 4 subfamily F member 2 (CYP4F2)Case-control studySingle nucleotide polymorphisms (SNPs)
spellingShingle Yuan Wu
Junjie Zhao
Yonglin Zhao
Tingqin Huang
Xudong Ma
Honggang Pang
Ming Zhang
Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
BMC Medical Genetics
Ischemic stroke (IS)
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2)
Case-control study
Single nucleotide polymorphisms (SNPs)
title Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_full Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_fullStr Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_full_unstemmed Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_short Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_sort genetic variants in cyp4f2 were significantly correlated with susceptibility to ischemic stroke
topic Ischemic stroke (IS)
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2)
Case-control study
Single nucleotide polymorphisms (SNPs)
url http://link.springer.com/article/10.1186/s12881-019-0888-6
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