Investigating the Role of the NLRP3 Inflammasome Pathway in Acute Intestinal Inflammation: Use of THP-1 Knockout Cell Lines in an Advanced Triple Culture Model

Investigating the Role of the NLRP3 Inflammasome Pathway in Acute Intestinal Inflammation: Use of THP-1 Knockout Cell Lines in an Advanced Triple Culture Model

The NLRP3 inflammasome plays an important role in intestinal homeostasis as well as inflammation. However, in vivo studies investigating the role of the NLRP3 inflammasome in inflammatory bowel disease (IBD) report contrasting results, leaving it unclear if the NLRP3 inflammasome augments or attenua...

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Bibliographic Details
Main Authors: Mathias Busch, Haribaskar Ramachandran, Tina Wahle, Andrea Rossi, Roel P. F. Schins
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
caco-2
HT29-MTX-E12
gastrointestinal tract
IBD
barrier
inflammatory disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.898039/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.898039/full

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