Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

Abstract The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor a...

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Bibliographic Details
Main Authors: Larissa B. Teixeira, Lucas T. Parreiras-e-Silva, Thiago Bruder-Nascimento, Diego A. Duarte, Sarah C. Simões, Rafael M. Costa, Deisy Y. Rodríguez, Pedro A. B. Ferreira, Carlos A. A. Silva, Emiliana P. Abrao, Eduardo B. Oliveira, Michel Bouvier, Rita C. Tostes, Claudio M. Costa-Neto
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-12074-3

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https://doi.org/10.1038/s41598-017-12074-3

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