The Use of Aryl-Substituted Homophthalic Anhydrides in the Castagnoli–Cushman Reaction Provides Access to Novel Tetrahydroisoquinolone Carboxylic Acid Bearing an All-Carbon Quaternary Stereogenic Center

The Use of Aryl-Substituted Homophthalic Anhydrides in the Castagnoli–Cushman Reaction Provides Access to Novel Tetrahydroisoquinolone Carboxylic Acid Bearing an All-Carbon Quaternary Stereogenic Center

Novel aryl-substituted homophthalic acids were cyclodehydrated to the respective homophthalic anhydrides for use in the Castagnoli–Cushman reaction. With a range of imines, this reaction proceeded smoothly and delivered hitherto undescribed 4-aryl-substituted tetrahydroisoquinolonic acids with remar...

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Bibliographic Details
Main Authors: Nazar Moshnenko, Alexander Kazantsev, Olga Bakulina, Dmitry Dar’in, Mikhail Krasavin
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
homophthalic anhydride
imine
Castagnoli–Cushman reaction
tetrahydroisoquinolone
lactam
all-carbon quaternary atom
Online Access:https://www.mdpi.com/1420-3049/27/23/8462

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https://www.mdpi.com/1420-3049/27/23/8462

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