Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients

Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients

Epidermolysis bullosa simplex (EBS) is a blistering skin disease caused by dominant-negative mutations in either KRT5 or KRT14, resulting in impairment of keratin filament structure and epidermal fragility. Currently, nearly 200 mutations distributed across the entire length of these genes are known...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Magomet Aushev, Ulrich Koller, Claudio Mussolino, Toni Cathomen, Julia Reichelt
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Elsevier 2017-09-01
Σειρά:Molecular Therapy: Methods & Clinical Development
Θέματα:
TALEN
keratins
intermediate filaments
KRT5
epidermolysis bullosa simplex
gene therapy
gene editing
non-homologous end joining
off-target effects
dominant negative mutations
Διαθέσιμο Online:http://www.sciencedirect.com/science/article/pii/S2329050117300839

Διαδίκτυο

http://www.sciencedirect.com/science/article/pii/S2329050117300839

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