Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30-60% higher than the heterozygotes. Female homozygous CYP46A1...

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Bibliographic Details
Main Authors: Silvia Maioli, Ann Båvner, Zeina Ali, Maura Heverin, Muhammad-Al-Mustafa Ismail, Elena Puerta, Maria Olin, Ahmed Saeed, Marjan Shafaati, Paolo Parini, Angel Cedazo-Minguez, Ingemar Björkhem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3712995?pdf=render

Internet

http://europepmc.org/articles/PMC3712995?pdf=render

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